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Target intelligence / Profile preview
Calcium Channel Protein L-type Subunit Alpha1C (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel, L-type calcium channel
01
Overview
The calcium channel protein L-type subunit alpha1C (CaV1.2) is the pore-forming alpha-1C subunit of the voltage-gated L-type calcium channel complex. It mediates the influx of Ca²⁺ into cells following membrane depolarization, playing a critical role in excitation-contraction coupling in cardiac muscle, smooth muscle function, and neuronal signaling. Mutations or dysregulation can be associated with disorders such as Timothy syndrome or Brugada syndrome.
- Other names
- Alpha 1CCACNA1C
02
Mechanism of action
Inhibition of calcium ion influx
03
Biological functions
Calcium ion influxExcitation-contraction couplingSmooth muscle contractionNeuronal signalingSecretionTissue developmentExcitability regulationExcitation-transcription couplingLearning and memory formationOsteoprotegerin regulation
04
Disease associations
Timothy syndromeBrugada syndromeArrhythmiasCardiac pathologies
05
Safety considerations
Cardiac arrhythmias
06
Interacting drugs
Dihydropyridines
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