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Calcium channel protein subunit alpha1C (CACNA1C)
- Target
- CACNA1C
- Molecular classification
- Ion channel, Voltage-gated calcium channel, L-type calcium channel
01
Overview
The CACNA1C gene encodes the alpha-1C subunit of a voltage-dependent L-type calcium channel (CaV1.2). This protein is crucial for mediating calcium influx into cells upon membrane depolarization, essential for cardiac action potentials, neurotransmission, gene expression, and other physiological processes. Mutations or dysregulation are linked to cardiac arrhythmias, neurodevelopmental disorders, and psychiatric conditions.
- Other names
- CACH2CACN2CACNL1A1CCHL11AVoltage-gated calcium channel subunit alpha Cav.12Voltage-dependent L-type calcium channel subunit alpha–IC
02
Mechanism of action
Calcium channel blocker
03
Biological functions
Muscle contractionNeurotransmitter releaseGene expressionCell-to-cell communicationCardiac action potential shapingSynaptic plasticityTranscriptional regulation
04
Disease associations
Timothy SyndromeLong QT SyndromeBrugada SyndromeShort QT SyndromeNeurodevelopmental disordersBipolar disorderSchizophreniaCardiac arrhythmia
05
Safety considerations
Cardiac arrhythmiasPotential for off-target effects due to widespread expression
06
Interacting drugs
Dihydropyridines
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