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Calcium Channel Protein Type 1 Subunit Alpha (L-type) (CACNA1x)
- Target
- CACNA1x
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The L-type calcium channel protein type 1 subunit alpha (α1 subunit) is the main pore-forming subunit of L-type voltage-gated calcium channels. It mediates Ca²⁺ influx into excitable cells upon membrane depolarization, playing a crucial role in excitation-contraction coupling in cardiac, skeletal, and smooth muscle. Different isoforms exist (Cav1.1-Cav1.4) with distinct tissue distributions. Mutations or dysregulation are implicated in various pathologies.
- Other names
- L-type calcium channel alpha 1 subunitCav1.1Cav1.2Cav1.3Cav1.4
02
Mechanism of action
Inhibition of L-type calcium channel activity
03
Biological functions
Calcium ion transportExcitation-contraction couplingVoltage sensingGating
04
Disease associations
ArrhythmiasPeriodic paralysis syndromesNeuropsychiatric disordersTimothy syndromeHypertensionImpaired muscular function
05
Safety considerations
Cardiac side effectsHypotension
06
Interacting drugs
Amlodipine
2 more in the full profile.
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