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Calcium channel protein type 1 subunit alpha1C (Cav1.2)
- Target
- Cav1.2
- Molecular classification
- Ion channel, Voltage-dependent calcium channel
01
Overview
The calcium channel protein type 1 subunit alpha1C (Cav1.2) is a pore-forming subunit of the voltage-dependent L-type calcium channel, encoded by the CACNA1C gene. It mediates calcium ion influx upon membrane depolarization, playing a crucial role in various physiological processes, including cardiac and smooth muscle contraction, neuronal signaling, and pancreatic function. Mutations and dysregulation of CACNA1C are associated with cardiac arrhythmias, Timothy syndrome, and psychiatric disorders. Dihydropyridines inhibit its activity.
- Other names
- CACNA1CL-type calcium channel alpha 1C subunit
02
Mechanism of action
Inhibition of L-type calcium channel activity
03
Biological functions
Calcium ion influxExcitation-contraction couplingNeuronal signalingSmooth muscle contractionPancreatic functionSecretion processesTissue developmentExcitability regulationExcitation–transcription couplingLearning and memory formation
04
Disease associations
Cardiac arrhythmiasBrugada syndromeTimothy syndromeBipolar disorderSchizophrenia
05
Safety considerations
Cardiac effects (arrhythmias, altered vascular tone)Potential for psychiatric side effects
06
Interacting drugs
Dihydropyridines
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