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Target intelligence / Profile preview
Calcium channel protein type 2 subunit alpha₁C (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The calcium channel protein type 2 subunit alpha₁C, encoded by the CACNA1C gene, is a critical component of voltage-dependent L-type calcium channels (CaV1.2). These channels mediate calcium influx upon membrane depolarization and are essential for muscle contraction, neurotransmission, secretion, and gene expression. Mutations in CACNA1C are associated with cardiac arrhythmias and neuropsychiatric conditions.
- Other names
- CACNA1CL-type calcium channel alpha 1C subunitVoltage-dependent L-type calcium channel subunit alpha-1C
02
Mechanism of action
Inhibition of calcium entry through L-type calcium channels
03
Biological functions
Cardiac muscle contractionSmooth muscle contractionNeurotransmissionSecretionGene regulationExcitation-contraction couplingExcitation-transcription coupling
04
Disease associations
Timothy SyndromeLong QT Syndrome Type 8Short QT SyndromeCardiac arrhythmiaNeuropsychiatric disorders
05
Safety considerations
Cardiac arrhythmiasHypotension (with dihydropyridines)
06
Interacting drugs
Dihydropyridines
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