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Target intelligence / Profile preview
Calcium Channel Protein Type L Subunit Alpha 1C (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-dependent calcium channel, L-type calcium channel
01
Overview
The calcium channel protein type L subunit alpha 1C, commonly referred to as CaV1.2 or encoded by the gene CACNA1C, is the pore-forming alpha-1 subunit of the voltage-dependent L-type calcium channel. This protein mediates the influx of calcium ions into cells upon membrane depolarization and plays a critical role in various physiological processes, especially in excitable tissues such as cardiac and smooth muscle, neurons, pancreatic cells, and fibroblasts.
- Other names
- CACNA1CCaVα₁cCaV₁.₂
02
Mechanism of action
Inhibition of L-type calcium channels
03
Biological functions
Voltage-gated Ca²⁺ entryExcitation-contraction couplingNeurotransmitter release regulationHormone secretion regulationGene expression regulation
04
Disease associations
Timothy SyndromeBrugada SyndromeBipolar DisorderSchizophreniaCardiovascular disease
05
Safety considerations
Cardiac arrhythmiasVascular pathologies
06
Interacting drugs
Dihydropyridines
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