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Target intelligence / Profile preview
Calcium Channel Protein Type L Subunit Alpha1C (Cav1.2)
- Target
- Cav1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The calcium channel protein type L subunit alpha1C (Cav1.2) is the pore-forming subunit of the voltage-dependent L-type calcium channel. It mediates the influx of calcium ions into cells upon membrane depolarization, playing a crucial role in excitation-contraction coupling in cardiac and smooth muscle, as well as hormone secretion and synaptic transmission. It is a target for dihydropyridine drugs used to treat hypertension and cardiac arrhythmias.
- Other names
- Voltage-dependent L-type calcium channel subunit alpha-1CCACNA1C
02
Mechanism of action
Calcium channel blockade
03
Biological functions
Calcium ion transmembrane transportExcitation-contraction couplingHormone secretionSynaptic transmissionRegulation of action potential duration
04
Disease associations
Cardiovascular diseaseHypertensionCardiac arrhythmia
05
Safety considerations
HypotensionCardiac conduction abnormalities
06
Interacting drugs
Dihydropyridines
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