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Target intelligence / Profile preview
Calcium channel protein type T
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
Calcium channel protein type T antagonists are compounds that block low-voltage activated Ca²⁺ entry through Cav3.x subfamily channels—modulating key physiological processes like neuronal firing and vascular tone—and have therapeutic potential especially for neurological disorders such as epilepsy and chronic pain syndromes.
- Other names
- T-type voltage-gated calcium channelCav3.x family
02
Mechanism of action
Inhibition of Ca²⁺ influx through T-type calcium channels
03
Biological functions
Regulation of cellular excitabilityPacemaking activityNeurotransmitter releaseMuscle contraction
04
Disease associations
EpilepsyPainCardiovascular diseasesNeurodegenerative diseases
05
Safety considerations
Potential for side effects due to widespread expressionChallenges in achieving selective peripheral inhibition
06
Interacting drugs
Z944
7 more in the full profile.
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