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Target intelligence / Profile preview
Calcium Channel Subunit (VGCC Subunit)
- Target
- VGCC Subunit
- Molecular classification
- Ion channel, Voltage-gated ion channel, Calcium channel, Transmembrane protein
01
Overview
Calcium channel subunits are the protein components that assemble to form calcium channels, which are essential for the regulation of calcium ion (Ca²⁺) flow across cell membranes. These channels play critical roles in various physiological processes, including muscle contraction, neurotransmitter release, gene expression, and hormone secretion. VGCCs are multi-subunit complexes composed of α1, β, α2δ, and γ subunits. The α1 subunit is the pore-forming unit. Auxiliary subunits regulate channel trafficking, gating, and pharmacology. Different VGCC types (L-, N-, P/Q-, R-, T-type) exhibit distinct tissue distributions and physiological roles, making them important drug targets for various diseases.
- Other names
- Voltage-gated calcium channel subunitCaV subunitα1 subunitβ subunitα2δ subunitγ subunit
02
Mechanism of action
Inhibition of calcium influx, modulation of channel gating, altered channel trafficking
03
Biological functions
Calcium ion transportMuscle contractionNeurotransmitter releaseHormone secretionGene expressionSignal transductionPacemaking activity
04
Disease associations
HypertensionAnginaArrhythmiasEpilepsyChronic painNeuropathic painPsychiatric disordersCancer
05
Safety considerations
Cardiovascular side effectsNeurological side effectsDrug interactions
06
Interacting drugs
Dihydropyridines
2 more in the full profile.
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