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Target intelligence / Profile preview
Calcium-Activated Chloride Channel (CaCC)
- Target
- CaCC
- Molecular classification
- Ion channel, Ligand-gated ion channel, Anoctamin/TMEM16 superfamily
01
Overview
Calcium-activated chloride channels (CaCCs) are a heterogeneous group of ligand-gated ion channels that mediate the flow of chloride ions across cell membranes in response to increases in intracellular calcium. The main molecular components identified are members of the anoctamin (TMEM16) family, particularly TMEM16A (also known as ANO1). Activation occurs when cytosolic Ca²⁺ binds to specific sites on the channel protein, triggering conformational changes that open the channel for Cl⁻ efflux or influx. CaCCs are widely expressed in both excitable and non-excitable cells and play major roles in epithelial secretion, sensory transduction, regulation of neuronal/cardiac excitability, and vascular tone control. Dysfunction or altered expression has been implicated in diseases affecting fluid secretion, hypertension, asthma, gastrointestinal motility disorders and some cancers.
- Other names
- Calcium-dependent chloride channelAnoctamin (ANO) familyTMEM16A/ANO1TMEM16B/ANO2
02
Mechanism of action
Block channel activity
03
Biological functions
Epithelial secretion of electrolytes/waterSensory transductionRegulation of neuronal/cardiac excitabilityVascular tone controlCl⁻ transportFluid secretionSmooth muscle contractionMembrane depolarization
04
Disease associations
Cystic fibrosis-like symptomsHypertensionAsthmaGastrointestinal motility disordersCancer
05
Safety considerations
Limited specificity of traditional blockersPharmacological profiles can vary between tissues
06
Interacting drugs
Niflumic acid (NFA)
1 more in the full profile.
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