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Calcium-Dependent Enzymes (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Hydrolase, Transferase, Oxidoreductase
01
Overview
Calcium-dependent enzymes are a diverse group of enzymes that require calcium ions (Ca2+) for their activity. Calcium typically acts as an allosteric regulator, binding to the enzyme and inducing conformational changes that affect its catalytic activity. These enzymes play crucial roles in various cellular processes, including signal transduction, metabolism, proteolysis, and blood coagulation. Examples include nitric oxide synthase, protein phosphatases, adenylate kinase, calpains (calcium-dependent proteases), calcium-dependent acyltransferases, enzymes of the tricarboxylic acid cycle (e.g., α-ketoglutarate dehydrogenase, isocitrate dehydrogenase, pyruvate dehydrogenase), mitochondrial glycerol 3-phosphate dehydrogenase, and gamma-carboxylases. Calcium is also involved in the maturation and transport of certain pro-enzymes.
- Other names
- Calcium-activated enzymesCa2+-dependent enzymes
02
Mechanism of action
N/A
03
Biological functions
CatalysisSignal transductionCellular regulationEnergy homeostasisProteolysisAcyl transferMetabolic regulationBlood coagulation
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseMetabolic disorders
05
Safety considerations
Potential for off-target effects due to broad calcium signaling involvementDysregulation can lead to various pathologies
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