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Target intelligence / Profile preview
Calcium-dependent potassium channel SLO-1 (SLO-1)
- Target
- SLO-1
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
SLO-1 is a large conductance, calcium- and voltage-activated potassium channel. It is a tetramer composed of four α subunits, each containing seven transmembrane segments. Activation leads to efflux of K⁺ ions, membrane hyperpolarization, and decreased cell excitability. Key functions include regulating smooth muscle contraction, neuronal excitability, auditory function, hormone secretion, and neurotransmitter release. Dysfunctions are linked to various diseases including hypertension, epilepsy, and autism spectrum disorders.
- Other names
- BK ChannelMaxi-K ChannelLarge-conductance calcium-activated potassium channelKCa1.1slo-1 (C. elegans)KCNMA1 (human/mammals)
02
Mechanism of action
Increase open probability of SLO-1 channels; inhibit SLO-1 activity
03
Biological functions
Regulation of membrane potentialRegulation of cell excitabilityRegulation of smooth muscle contractionModulation of neuronal excitabilityAuditory functionHormone secretionNeurotransmitter releaseEfflux of K⁺ ions
04
Disease associations
HypertensionOveractive bladder/urinary incontinenceEpilepsyIntellectual disability/autism spectrum disordersMuscle degeneration (C. elegans)
05
Safety considerations
Off-target effects of some activators (e.g., NS1619) on other ion channelsTissue-specific gating properties and pharmacological sensitivities conferred by auxiliary β-subunits need to be considered.
06
Interacting drugs
NS1619
2 more in the full profile.
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