Calcium homeostasis modulator family member 6 (CALHM6)

Calcium homeostasis modulator family member 6 (CALHM6) is a membrane protein classified as a pore-forming subunit of a voltage-gated ion channel, structurally part of the CALHM family of cation channels[1][2]. The protein is predicted to facilitate the export of ATP and transmembrane monoatomic cation movement and is implicated in the regulation of natural killer (NK) cell responses and immune synapse signaling, actively relocating to NK-dendritic and NK-macrophage synapses upon proinflammatory stimuli to mediate ATP-dependent immune activation[1]. While diseases such as nephrotic syndrome have been associated with mutations in CALHM6, its specific pathophysiological roles and potential for drug targeting are less characterized than other ion channels; no approved drugs directly modulate CALHM6 as a primary target as of the referenced material[1]. The CALHM6 gene is also known as FAM26F, among other aliases, and belongs to the CALHM gene family (CALHM1–6), whose other members have better-established functions in neural and sensory biology[3]. *If more targeted information or up-to-date data are needed (e.g., emerging drug programs), additional specialized databases or recent literature may need to be consulted, as direct pharmacological targeting of CALHM6 is not yet established in major resources.*

Other names

FAM26FC6orf187Calcium homeostasis modulator protein 6IFN regulatory factor 3-dependent NK-activating molecule