Calcium ion stores

The term "Calcium ion stores" refers to intracellular organelles, mainly the endoplasmic reticulum (ER) in non-muscle cells and the sarcoplasmic reticulum (SR) in muscle cells, where high concentrations of calcium ions are sequestered and released as needed to regulate key cellular processes[1][3]. The content of these stores is controlled by various pumps (notably SERCA) that move calcium into the compartment and channels (principally the ryanodine receptor and IP3 receptor) that release calcium into the cytoplasm[1]. The controlled release and uptake of calcium from these stores enable vital biological processes such as muscle contraction, neurotransmitter release, and regulation of gene expression[1][3]. Depletion of calcium stores triggers "store-operated calcium entry" (SOCE) via plasma membrane channels (like Orai1/CRAC), coordinated by ER-resident sensors (STIM proteins)[1][3]. Calcium store dysfunction is implicated in diseases including heart failure, neurodegeneration, and muscle disorders. Note: - "Calcium ion stores" is not a specific druggable protein, enzyme, receptor, or channel. It is a subcellular compartment defined by its function, not a discrete molecular entity. - For drug discovery or pharmacology, molecular targets would be the channels, pumps, or sensors regulating the stores (e.g., SERCA, IP3 receptor, ryanodine receptor, Orai1, STIM1)[1][3]. - Any structured database or ontology would denote "Calcium ion stores" as a physiological feature, not a canonical molecular target[1][3].

Other names

Calcium storesintracellular calcium storesER calcium storeSR calcium storecellular calcium stores