Calcium-phosphorus metabolism regulation pathway

"Calcium-phosphorus metabolism regulation pathway" is not a discrete molecular target, receptor, or protein, but rather refers to a complex physiological pathway that integrates hormonal, cellular, and organ-level controls governing calcium and phosphate levels in the body[1][2][3][6]. Key endocrine regulators include parathyroid hormone (PTH), 1,25-dihydroxyvitamin D (calcitriol), and fibroblast growth factor 23 (FGF23), which coordinate the absorption, reabsorption, storage, and excretion of calcium and phosphate via the intestines, kidneys, and bone[1][2][3][6]. Disruptions in this pathway underlie numerous systemic diseases such as rickets, hereditary hypophosphatemic rickets, and chronic kidney disease. Because the pathway encompasses many hormones and transporters, it cannot be considered a single "therapeutic target" in the molecular sense, but rather a regulatory network. Thus, this entry is not a valid precise molecular target, but instead represents a complex physiological process[1][2].

Other names

Calcium and phosphate homeostasisCalcium-phosphorus metabolism