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Target intelligence / Profile preview
Calcium release-activated calcium channel protein 2 (Orai2)
- Target
- Orai2
- Molecular classification
- Ion channel, Calcium channel, Integral membrane protein
01
Overview
Orai2 is a protein subunit of the calcium release-activated calcium (CRAC) channel, essential for store-operated calcium entry (SOCE) into cells. It is activated by STIM proteins upon depletion of Ca²⁺ stores in the endoplasmic reticulum and enables Ca²⁺ influx across the plasma membrane, playing a critical role in immune cell function, growth factor responses, neurotransmitter signaling, and cancer progression. CRAC channel activity is regulated by fast Ca²⁺-dependent inactivation (FCDI) to prevent excessive Ca²⁺ influx. Alterations or dysregulation of *ORAI2* are linked with immunodeficiency syndromes and cancer.
- Other names
- C7orf19CBCIP2MEM142BTMEM142B
02
Mechanism of action
Store-operated calcium channel inhibition
03
Biological functions
Store-operated calcium entryImmune cell signalingRegulation of growth factor responsesNeurotransmitter signaling
04
Disease associations
Immunodeficiency syndromesCancer
05
Safety considerations
Excessive Ca²⁺ influx leading to cellular toxicityPotential for immune dysregulation
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