Calcium release-activated channel regulator 2B (CRACR2B)

Calcium release-activated channel regulator 2B (CRACR2B) is a protein-coding gene that encodes a regulator protein involved in store-operated calcium entry (SOCE), an essential biological pathway for calcium influx in non-excitable cells. CRACR2B binds calcium ions and participates in the activation or modulation of CRAC channels, which replenish endoplasmic reticulum calcium stores and are vital for diverse cellular functions, including immune cell activation and gene expression[1][4][5]. Mutations or dysregulation in the SOCE pathway, including its regulators, are linked to disorders such as developmental and epileptic encephalopathies. Unlike the core CRAC channel pore-forming proteins (e.g., Orai1), CRACR2B acts as a regulator and is not itself the channel pore; it is essential for proper Ca2+ signaling and immune responses but has not been established as a direct pharmacological target to date[1].

Other names

CRACR2BEFC4AEF-hand calcium-binding domain-containing protein 4A

Store-operated calcium channel modulation (modifies SOCE pathway via regulation of CRAC channel activation) Not a primary drug target itself, but acts upstream/in concert with CRAC channel components