Calcium release for remineralization

“Calcium release for remineralization” refers to the process by which calcium ions become bioavailable in the oral cavity to enable the natural repair of demineralized tooth enamel. Remineralization occurs when calcium, phosphate, and sometimes fluoride ions are deposited into voids created in enamel during acid challenge. These ions can be supplied from saliva, dietary sources, or therapeutic agents (toothpastes, varnishes, etc.), favoring the formation of hydroxyapatite or, in the presence of fluoride, more acid-resistant fluorapatite. This process counteracts dental caries and erosion, restoring the integrity and strength of enamel. It is not a single molecular target, but rather involves physical chemistry and the interplay of ionic species in oral fluids and on enamel surfaces[1][3][4][5][7].

Other names

Tooth remineralizationEnamel remineralizationDental remineralization

Inorganic ions (e.g., fluoride, calcium, phosphate) are supplied to the oral environment, promoting the deposition of new mineral into enamel and filling crystal voids; Formation of acid-resistant fluorapatite in the presence of fluoride[1][4][5]; Agents create conditions favoring supersaturation to enable remineralization[2][3][7]