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Target intelligence / Profile preview
Calcium-transporting ATPase type 2C member 1 (ATP2C1)
- Target
- ATP2C1
- Molecular classification
- P-type cation transport ATPase, Enzyme, Transporter
01
Overview
Calcium-transporting ATPase type 2C member 1 (ATP2C1) is a P-type cation transport ATPase that transports Ca²⁺ and Mn²⁺ into the Golgi apparatus. It is essential for calcium and manganese homeostasis, protein sorting, and Golgi morphology. Mutations in ATP2C1 cause Hailey-Hailey disease, a skin disorder characterized by impaired cell adhesion among keratinocytes.
- Other names
- hSPCA1AT2C1_HUMANPMR1secretory pathway Ca(2+)/Mn(2+) ATPase 1KIAA1347HHD
02
Biological functions
Calcium ion transmembrane transportManganese ion transmembrane transportRegulation of protein processing within secretory pathwaysMaintenance of epidermal structureCalcium homeostasis
03
Disease associations
Hailey-Hailey disease
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