Calcium-transporting ATPase type 2C member 2 (SPCA2)

Calcium-transporting ATPase type 2C member 2 (SPCA2, gene symbol ATP2C2) is a P-type ATPase enzyme and ion transporter localized primarily in the Golgi apparatus membranes. It uses ATP hydrolysis to pump calcium and manganese ions from the cytosol into the Golgi lumen, thus playing critical roles in maintaining cytosolic calcium and manganese homeostasis, supporting processing and trafficking of newly synthesized proteins, and contributing to specialized physiological functions such as milk secretion in the mammary gland[1][2][6]. SPCA2 is implicated in disease states including autism spectrum disorder and triple-receptor negative breast cancer. It may regulate mitochondrial respiration, the cellular response to DNA damage, and can interact with plasma membrane calcium channels to facilitate calcium entry independently of organelle stores[1][2][5][6].

Other names

SPCA2 (Secretory pathway Ca2+-ATPase 2)ATP2C2 (gene symbol)Calcium pump 2Secretory pathway calcium ATPase 2

For hypothetical drugs targeting this molecule: - Inhibition: would reduce Golgi calcium/manganese loading, potentially impairing protein processing or secretion (INFERRED). - Activation/enhancement: would support calcium/manganese sequestration, possibly limiting cytosolic toxicity and supporting protein maturation in secretory cells (INFERRED).