Calcium uptake protein 3, mitochondrial (MICU3)

Calcium uptake protein 3, mitochondrial (MICU3) is a calcium-binding regulatory protein localized to the mitochondrial intermembrane space and is a component of the mitochondrial calcium uniporter complex, which modulates mitochondrial calcium uptake[1][2][4]. MICU3 often forms a heterodimer with MICU1, enhancing mitochondrial calcium uptake, especially in neuronal presynapses and cardiac myocytes[4][5]. Experimental findings show that MICU3 is necessary for proper physiological mitochondrial calcium regulation: its overexpression promotes increased calcium uptake and can trigger cardiac hypertrophy with reduced heart function, while knockout reduces mitochondrial calcium responses to adrenergic stimulation[1][2]. Decreased MICU3 protein/expression is observed in human heart failure samples, implicating it in cardiovascular disease processes and as a possible therapeutic target[1][2]. There is no evidence of interacting drugs or use as a direct biomarker outside research settings.

Other names

EFHA2hMICU3DKFZp313A0139EF-hand domain-containing family member A2EF-hand domain family A2EF-hand domain family, member A2mitochondrial uptake family, member 3Micu3 protein, mouse

Modulation of mitochondrial calcium uniporter activity (no drugs documented)