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Calcium voltage-gated channel auxiliary subunit alpha2delta 1 (CACNA2D1)
- Target
- CACNA2D1
- Molecular classification
- Ion channel subunit, Voltage-gated calcium channel subunit, Auxiliary subunit
01
Overview
CACNA2D1 encodes an essential auxiliary component of voltage-gated calcium channels that modulates their biophysical properties. It plays key roles in neuronal signaling and muscular contraction while serving as an important drug target for anticonvulsant therapies. Its dysfunction has been implicated in diverse diseases ranging from epilepsy syndromes to metabolic disorders like diabetes—and it remains under investigation both as a therapeutic target itself and as part of broader neurophysiological processes.
- Other names
- alpha-2/delta-1 subunit of voltage-dependent calcium channelsalpha2delta 1Voltage-dependent calcium channel subunit alpha‑2/delta‑1
02
Mechanism of action
Binding to alpha2delta 1 and modulating calcium channel function
03
Biological functions
Regulation of calcium current densityModulation of calcium channel kineticsNeurotransmitter releaseMuscle contractionGene expressionSynaptogenesisModulation of synaptic transmission
04
Disease associations
Developmental And Epileptic Encephalopathy 110Familial Short QT SyndromeEpilepsyNeuropathic painDiabetes susceptibilityGlaucomaColon cancerSpinal cord injury-induced neuropathic pain
05
Interacting drugs
Gabapentin
1 more in the full profile.
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