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Target intelligence / Profile preview
Calcium voltage-gated channel auxiliary subunit gamma-2 (CACNG2)
- Target
- CACNG2
- Molecular classification
- Ion channel auxiliary subunit, Transmembrane AMPA receptor regulatory protein (TARP), Voltage-gated calcium channel auxiliary subunit
01
Overview
Calcium voltage-gated channel auxiliary subunit gamma-2 (CACNG2), also known as stargazin or TARP gamma-2, is a type I transmembrane protein primarily expressed in the brain, where it acts as an auxiliary subunit of voltage-gated calcium channels and as a regulatory protein for AMPA-type glutamate receptors[1][2][3][7]. CACNG2 facilitates trafficking and synaptic targeting of AMPA receptors and modulates their gating kinetics, playing a vital role in synaptic plasticity, learning, memory, and neuronal excitability[2][4][7]. Mutations or dysregulation of CACNG2 are associated with seizure disorders, intellectual disability, autism, and altered pain perception in both humans and animal models[1][3]. No specific drugs are currently known to target CACNG2 directly, but its modulation impacts AMPA receptor function and calcium channel activity, making it an emerging target for neurological and psychiatric disorders.
- Other names
- Voltage-dependent calcium channel gamma-2 subunitStargazinTARP gamma-2MRD10Transmembrane AMPAR regulatory protein gamma-2Neuronal voltage-gated calcium channel gamma-2 subunitMGC138502MGC138504
02
Mechanism of action
Modulation of AMPA receptor (AMPAR) trafficking and channel gating; Stabilization of voltage-gated calcium channels in the inactivated state
03
Biological functions
Synaptic plasticityRegulation of AMPA receptor trafficking and gatingLearning and memorySignal transductionRegulation of neuronal excitability
04
Disease associations
Neurodevelopmental diseaseIntellectual disability (autosomal dominant intellectual developmental disorder 10)Autism spectrum disorderEpilepsy and seizure disordersNeuropathic pain
05
Safety considerations
Mutations linked to cognitive disability and seizures[1][2]Disruption can affect synaptic plasticity, learning, and pain perception[3]
06
Biomarkers
SNPs in CACNG2 as biomarkers for response in mood disorders and pain susceptibility[3]
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