Calcium voltage-gated channel auxiliary subunit gamma 5 (CACNG5)

Calcium voltage-gated channel auxiliary subunit gamma 5 (CACNG5) is a type II transmembrane protein that belongs to the family of gamma subunits of voltage-dependent calcium channels and is also classified as a transmembrane AMPA receptor regulatory protein (TARP)[1][5][8]. CACNG5 regulates AMPA-type glutamate receptors (AMPARs) by accelerating their rates of activation, deactivation, and desensitization, and it shows specificity for certain AMPAR subunits such as GRIA1, GRIA4, and the long isoform of GRIA2[5][1][8]. It stabilizes voltage-gated calcium channels in an inactivated state, thus modulating neuronal excitability[8][1]. CACNG5 is involved in neurotransmitter receptor internalization and trafficking and is genetically associated with increased risk of psychiatric disorders, including bipolar disorder and schizophrenia[1][6]. There are currently no clinically approved drugs that specifically target CACNG5.

Other names

Voltage-dependent calcium channel gamma-5 subunitCalcium channel, voltage-dependent, gamma subunit 5Neuronal voltage-gated calcium channel gamma-5 subunitTransmembrane AMPAR regulatory protein gamma-5TARP gamma-5

Modulation of AMPA receptor trafficking and gating; Modulation of voltage-dependent calcium channel properties