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Calcium voltage-gated channel auxiliary subunit gamma-6 (CACNG6)
- Target
- CACNG6
- Molecular classification
- Ion channel auxiliary subunit, Transmembrane protein, PMP-22/EMP/MP20 protein family
01
Overview
Calcium voltage-gated channel auxiliary subunit gamma-6 (CACNG6) is an integral membrane protein that functions as an auxiliary subunit of voltage-gated calcium channels, particularly L-type channels. It contributes to modulation of channel activity by stabilizing the channel in an inactive (closed) state and may play additional roles in neuronal signaling and AMPA receptor regulation. CACNG6 is part of the PMP-22/EMP/MP20 protein family and has implications in several diseases, including arrhythmogenic right ventricular cardiomyopathy, depressive disorder, and aspirin-intolerant asthma. Although it is a bona fide molecular target as an ion channel auxiliary subunit, there are currently no drugs known to specifically target CACNG6[1][3][8].
- Other names
- Voltage-dependent calcium channel gamma-6 subunitNeuronal voltage-gated calcium channel gamma-6 subunitCalcium channel, voltage-dependent, gamma subunit 6Calcium voltage-gated channel auxiliary subunit γ 62310033H20RIKAW050150
02
Biological functions
Regulation of L-type calcium channel activityStabilization of voltage-gated calcium channel in the inactive (closed) stateModulation of neuronal excitabilityPotential involvement in AMPA receptor regulation
03
Disease associations
Depressive disorderArrhythmogenic right ventricular cardiomyopathyAspirin-intolerant asthmaNeuropsychiatric conditions (e.g., possible risk gene for schizophrenia)
04
Safety considerations
Potential impact on cardiac and neuronal function due to modulation of calcium channel activityRisk of arrhythmia if dysregulatedAssociation with asthma, neuropsychiatric, and cardiac disorders[1][3][8]
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