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Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8
- Molecular classification
- TARP, Auxiliary Subunit, Voltage-Gated Calcium Channel Subunit
01
Overview
CACNG8 encodes a type I transmembrane protein that is part of the gamma subunit family of voltage-gated calcium channels. It acts as an auxiliary subunit, primarily regulating the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), which are critical for fast excitatory synaptic transmission in the central nervous system. CACNG8 promotes targeting of these receptors to the cell membrane and synapses, thereby influencing synaptic strength and plasticity. Additionally, it can stabilize L-type calcium channels.
- Other names
- CCG8 proteinTARP γ-8
02
Mechanism of action
CACNG8 inhibitors bind to its gamma subunit within voltage-gated calcium channels (VGCCs), modifying channel properties—potentially affecting neuronal signaling or excitability through altered receptor/channel function
03
Biological functions
Regulation of AMPA receptor traffickingModulation of AMPA receptor gatingStabilization of voltage-gated calcium channelsRegulation of synaptic transmissionModulation of synaptic plasticity
04
Disease associations
Antisocial Personality DisorderRetinitis Pigmentosa 32Attention-Deficit Hyperactivity Disorder (ADHD)
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