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Target intelligence / Profile preview
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Cav2.1)
- Target
- Cav2.1
- Molecular classification
- Ion channel, Voltage-gated calcium channel, P/Q-type calcium channel subunit
01
Overview
The voltage-dependent P/Q-type calcium channel subunit alpha-1A is the pore-forming α1 subunit of the neuronal Cav2.1 (P/Q-type) high-voltage activated (HVA) calcium channels. These channels mediate the entry of Ca²⁺ ions into excitable cells and are crucial for a variety of physiological processes.
- Other names
- CACNA1Acalcium voltage-gated channel subunit alpha1 A
02
Mechanism of action
Selective block of P/Q-type calcium channels.
03
Biological functions
Neurotransmitter releaseRegulation of gene expressionNeuronal excitabilitySynaptic plasticityMuscle contractionHormone releaseCell motilityCell divisionCell deathHigh voltage-gated Ca²⁺ activityMetal ion bindingSyntaxin bindingAmyloid-beta binding
04
Disease associations
Familial hemiplegic migraine type 1 (FHM)Episodic ataxia type 2 (EA2)Spinocerebellar ataxia type 6 (SCA6)EpilepsyCerebellar dysfunctionNeurological disorders
05
Safety considerations
Altered Ca²⁺ influxAffects neurotransmission
06
Interacting drugs
ω-agatoxin IVA
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