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Calcium voltage-gated channel subunit alpha1G (Cav3)
- Target
- Cav3
- Molecular classification
- Ion channel, Voltage-gated calcium channel, T-type calcium channel
01
Overview
Calcium voltage-gated channel subunit alpha1G (Cav3) is a pore-forming subunit of T-type calcium channels. These channels are responsible for mediating the entry of Ca²⁺ ions into excitable cells in response to membrane depolarization. Cav3 channels open at more negative membrane potentials than other voltage-gated Ca²⁺ channels and quickly inactivate after opening, producing transient currents. They are involved in pacemaking activity, regulation of neuronal firing patterns, calcium signaling, muscle contraction, hormone/neurotransmitter release, gene expression, and cell motility/division/death. Alterations or dysfunctions involving Cav3/T-type channels have been implicated in epilepsy, neuropathic pain syndromes, sleep disorders, and arrhythmias.
- Other names
- Cav3.1T-type calcium channel alpha 1G subunitCACNA1G
02
Mechanism of action
T-type calcium channel blocker
03
Biological functions
Ion transmembrane transportRegulation of neuronal excitabilityPacemaking activityRegulation of heart rateCalcium signaling
04
Disease associations
EpilepsyNeuropathic painSleep disordersArrhythmiasBradycardiaTachycardia
05
Interacting drugs
Mibefradil
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