Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Calcyphosine-like protein (CAPSL)
- Target
- CAPSL
- Molecular classification
- EF-hand domain-containing protein, Calcium-binding protein
01
Overview
Calcyphosine-like protein (CAPSL) is a calcium-binding protein with EF-hand domains predicted to localize to the cytoplasm and play multifaceted roles in cell biology, including calcium ion signaling, regulation of adipocyte differentiation, fat metabolism, cell migration, and immune response modulation[1][3][5]. Genetic association studies have implicated CAPSL loci in autoimmune diseases like type 1 diabetes and Graves’ disease[1], while functional studies show down-regulation in adipose tissue of patients with multiple symmetric lipomatosis, with experimental evidence supporting its role in adipogenesis, lipogenesis, autophagy, and sirtuin-1 expression[1][4]. No drugs currently target CAPSL directly, and it is not considered a classical druggable target such as a receptor, enzyme, or ion channel[1][4][8].
- Other names
- Calcyphosine-like proteinCAPSLMGC26610calcyphosin-like protein
02
Biological functions
Calcium ion bindingRegulation of ion transportAdipogenesis (adipocyte differentiation)Modulation of immune responsesCell migration during development (morphogenesis)
03
Disease associations
Type 1 diabetes (association/modulation)Autoimmune thyroid disease (Graves’ disease)Multiple Symmetric Lipomatosis/ LipomatosisOther (implicated, but not clearly established in cancer, metabolic syndrome, etc.)
04
Biomarkers
Reduced CAPSL expression may serve as a biomarker in Multiple Symmetric LipomatosisCAPSL genetic variants (e.g., rs1445898) may modulate type 1 diabetes susceptibility
Beyond the preview
Go deeper on Calcyphosine-like protein (CAPSL).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Calcyphosine-like protein (CAPSL).