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Target intelligence / Profile preview
CALHM6 antisense RNA 1 (CALHM6-AS1)
- Target
- CALHM6-AS1
- Molecular classification
- Antisense RNA, Long non-coding RNA (lncRNA)
01
Overview
CALHM6 antisense RNA 1 is a non-coding RNA transcript processed from the genomic region antisense to the CALHM6 gene, involved in modulating the expression of CALHM6 by mechanisms common to antisense RNAs such as transcriptional interference or mRNA stability regulation[5][2][3]. CALHM6-AS1 itself does not encode a protein, but its regulatory role may influence CALHM6, an ion channel involved in ATP export, immune synapse function, and the activation of natural killer cells[4][1]. There is currently no evidence that CALHM6-AS1 functions as a direct therapeutic target, nor is it known to be the focus of drug development or used as a biomarker in clinical settings.
- Other names
- RP1-93H18.6
02
Mechanism of action
Not applicable (as a non-protein-coding antisense RNA, mechanism would be regulatory over the CALHM6 gene, not a pharmacological action)
03
Biological functions
Regulation of gene expression (via antisense mechanisms at transcriptional and/or post-transcriptional stages)Potential epigenetic modulation (inferred from general antisense lncRNA roles)
04
Disease associations
Other (functional/disease impact not specifically described for CALHM6-AS1; antisense RNAs can be implicated in imprinting, cancer, and immune response modulation, but no direct disease association has been reported)
05
Safety considerations
Not applicable (no therapeutic exploitation known; general concerns with targeting lncRNAs include off-target effects and difficulty in delivery)
06
Interacting drugs
None reported (no evidence for direct drug targeting or chemical interaction)
07
Biomarkers
None reported (no clinical biomarker usage is known for CALHM6-AS1)
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