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Target intelligence / Profile preview
Calicin (CCIN)
- Target
- CCIN
- Molecular classification
- Other, Cytoskeletal protein, BTB (POZ) domain-containing protein, Kelch repeat-containing protein
01
Overview
Calicin (CCIN) is a basic, testis-specific cytoskeletal protein and a major structural component of the perinuclear theca (PT), specifically the postacrosomal "calyx" region of the mammalian sperm head[2][3]. It is characterized by kelch repeats and a BTB/POZ domain and shows strong homology to other actin-associated proteins, suggesting a role in actin network organization and cytoskeletal stability[3][2]. Calicin stabilizes the structural integrity and precise morphology of the sperm head during spermatogenesis[1][2]. Its expression is restricted to testicular germ cells, and it is essential for male fertility; mutations or dysregulation can cause acrosome detachment, sperm head deformities, and male infertility such as globozoospermia[1][2][3]. The protein is not considered a classical therapeutic target such as a receptor or enzyme, and there are no known drugs targeting CCIN. However, defective CCIN protein or gene mutations serve as biomarkers for specific types of male infertility.
- Other names
- CalicinCCINKBTBD14BTBD20SPGF91testis tissue sperm-binding protein Li 65n
02
Biological functions
Structural support of sperm head cytoskeletonMaintenance of sperm head shapeRegulation of perinuclear theca integrityInvolvement in spermatogenesis and spermiogenesisMediation of acrosome-nucleus attachmentActin-binding and regulation of actin dynamicsRedox stress response and cytoskeletal remodeling
03
Disease associations
Male infertility (including globozoospermia and morphological sperm defects)Associated with sperm malformations leading to impaired fertilization
04
Biomarkers
Mutation or deficiency of CCIN as a marker for male infertility and teratozoospermia
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