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Target intelligence / Profile preview
Calmodulin (CaM)
- Target
- CaM
- Molecular classification
- Calcium-binding protein, Regulatory protein
01
Overview
Calmodulin is a ubiquitous eukaryotic protein acting as a dynamic sensor/transducer for intracellular calcium signals. Its unique structure enables broad regulatory control over hundreds of downstream effectors vital for cell physiology. Disruption or mutation leads directly to disease states due to loss or misregulation of these essential signaling networks.
- Other names
- CaMCALM1CALM2CALM3
02
Mechanism of action
Binds to and modulates the activity of target proteins in a calcium-dependent manner.
03
Biological functions
Signal transductionCalcium signalingRegulation of enzyme activityRegulation of ion channel activityMuscle contractionNeurotransmitter releaseCell cycle progressionMetabolism regulationGene expression controlMaintenance of cellular homeostasis
04
Disease associations
CardiomyopathyCancerNeurological disorders
05
Safety considerations
Off-target effects due to broad target range.Potential for disruption of multiple cellular processes.
06
Interacting drugs
Calmidazolium
2 more in the full profile.
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