Calmodulin-3 (CALM3)

Calmodulin-3 is a highly conserved, small calcium-binding protein encoded by the CALM3 gene on human chromosome 19q13.32. It acts as a universally expressed intracellular sensor and signal transducer by binding calcium ions and controlling the activity of a wide spectrum of target proteins including kinases, phosphatases, ion channels, and other enzymes. Calmodulin-3 contributes to essential cellular processes including regulation of the cell cycle, cytokinesis, centrosome function, and most critically, excitation-contraction coupling in cardiac muscle. Pathogenic CALM3 mutations are strongly linked to cardiac arrhythmia syndromes such as Long QT syndrome and catecholaminergic polymorphic ventricular tachycardia, which can lead to life-threatening events even in young individuals. Due to its ubiquitous roles in cellular signaling, calmodulin is not a traditional drug target, but small molecule inhibitors (such as trifluoperazine) and calcium-like agents are known to interact with it. Monitoring of CALM3 mutations can serve as a biomarker for inherited cardiac arrhythmia risk[1][2][3].

Other names

Calmodulin-3CALML2CAM3CAMCCAMIIIPHKDPHKD3prepro-calmodulin 3phosphorylase kinase subunit deltaphosphorylase kinase subunit delta 3CALMCAM1CAM2CAMBCPVT6CaMCaMIIIHEL-S-72LQT16Calmodulin-1Calmodulin-2epididymis secretory protein Li 72

Calcium-dependent modulation of target enzymes (e.g., kinases such as CaMK2, myosin light chain kinase). Inhibition of calmodulin function by direct binding (e.g., by trifluoperazine). Modulation of signaling pathways via calcium binding and release.