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Target intelligence / Profile preview
Calmodulin-dependent Cyclic Nucleotide Phosphodiesterase (PDE1)
- Target
- PDE1
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Calmodulin-dependent cyclic nucleotide phosphodiesterases (PDE1s) are a family of enzymes that hydrolyze cAMP and cGMP, terminating signaling events. Their activity is regulated by calcium/calmodulin, integrating calcium and cyclic nucleotide pathways. PDE1s participate in diverse physiological processes and are potential drug targets.
- Other names
- CaM-PDECalmodulin-stimulated phosphodiesterase
02
Mechanism of action
PDE1 inhibitors block the hydrolysis of cAMP and cGMP, increasing their intracellular concentrations and prolonging their signaling effects.
03
Biological functions
Signal transductionRegulation of cyclic nucleotide signalingRegulation of gene transcriptionNeuronal functionCardiac muscle contractionVascular relaxationCell proliferationBlood coagulationNeurotransmitter metabolism
04
Disease associations
Neurodegenerative diseaseCardiovascular diseaseInflammationNeurological disorders
05
Safety considerations
Off-target effects due to homology with other PDEsPotential for drug-drug interactions
06
Interacting drugs
Ginseng extracts
3 more in the full profile.
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