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Calmodulin-like protein 3 (CALML3)
- Target
- CALML3
- Molecular classification
- Other (EF-hand calcium-binding protein, calmodulin family)
01
Overview
Calmodulin-like protein 3 (CALML3) is a calcium-binding protein encoded by the CALML3 gene, and is structurally related to calmodulin[1][2][4][5]. It may act as a specific light chain for unconventional myosin-10 (MYO10), potentially enhancing MYO10 translation or serving as a chaperone for the emerging MYO10 heavy chain[1][5]. CALML3 can bind calcium ions and may compete with calmodulin by interacting with different cellular substrates. It is mainly located in extracellular exosomes. Although related to disease pathways and some conditions, CALML3 is not a recognized drug target or receptor and has no established interacting drugs or known biomarker uses[1][4][5].
- Other names
- Calmodulin-like protein 3CALML3CLPCaM-like proteinCalmodulin-related protein NB-1
02
Biological functions
Calcium ion bindingPossible regulation of unconventional myosin-10 (MYO10) functionPossible chaperone activity for MYO10Cellular signaling
03
Disease associations
Other (associated with Otomycosis and Sporotrichosis, but not a classical target in disease therapeutics)
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