Target intelligence / Profile preview

Calmodulin-like protein 6 (CALML6)

Target
CALML6
Molecular classification
Calcium-binding protein, EF-hand family protein, Other
01

Overview

Calmodulin-like protein 6 (CALML6) is a member of the calmodulin family of calcium-binding proteins, characterized by EF-hand motifs that mediate calcium ion binding[1][2][6]. CALML6 is thought to play a role in intracellular calcium signaling pathways, which regulate diverse cellular processes such as muscle contraction, cell growth, immune responses, and potentially neurological functions[1][2]. It is expressed in a range of tissues, including brain, muscle, and immune cells, and is located in both the cytoplasm and nucleus[1][2][4][6]. While altered expression of CALML6 has been associated with certain types of cancer, neurological disorders, and infection responses[1][2], its precise physiological and pathological roles remain incompletely defined and are currently under investigation. No drugs are known to target this protein directly, and it is not an established therapeutic target based on current data[1][2][6].

Other names
CALML6CAGLPCalglandulin-like proteincalmodulin-like protein 6EF-hand proteinCALGP
02

Mechanism of action

Not applicable (no known drugs/interactions)

03

Biological functions

Calcium ion bindingModulation of enzyme activityRegulation of microtubule cytoskeleton organizationPutative involvement in immune response and neurological processes (putative/needs further study)
04

Disease associations

Cancer (expression changes observed in some cancers)Neurological disease (possible connection to Alzheimer’s disease and other conditions; not firmly established)Infection (possible role in response to anthrax)Other (roles are emerging/not fully defined; further investigation needed)
05

Safety considerations

None notable or described in the literature
06

Interacting drugs

None known
07

Biomarkers

None established

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