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Target intelligence / Profile preview
Calpain 1
- Molecular classification
- Enzyme, Protease, Cysteine protease
01
Overview
Calpain 1 is a calcium-activated, non-lysosomal cysteine protease that plays a key role in various cellular processes, including cytoskeletal remodeling and signal transduction. It functions as part of a heterodimeric complex composed of a large catalytic subunit (encoded by CAPN1) and a common small regulatory subunit (CAPNS1/CAPN4). Activation requires micromolar concentrations of intracellular Ca²⁺ ions. Dysregulation or aberrant activation has been implicated in several diseases, including Alzheimer's disease.
- Other names
- CANPCANP1CANPL1muCANPmuCLSPG76calpain 1
02
Mechanism of action
Calpain inhibition
03
Biological functions
Cytoskeletal remodelingSignal transductionLimited proteolysisCell differentiation
04
Disease associations
Neurodegenerative diseaseAlzheimer's diseaseOther
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