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Calpain 1 (None)

Target: None
Molecular classification: Enzyme, Protease, Cysteine protease

Overview

Calpain 1 is a calcium-activated, non-lysosomal cysteine protease that plays a key role in various cellular processes, including cytoskeletal remodeling and signal transduction. It functions as part of a heterodimeric complex composed of a large catalytic subunit (encoded by CAPN1) and a common small regulatory subunit (CAPNS1/CAPN4). Activation requires micromolar concentrations of intracellular Ca²⁺ ions. Dysregulation or aberrant activation has been implicated in several diseases, including Alzheimer's disease.

Other names: CANPCANP1CANPL1muCANPmuCLSPG76calpain 1

Mechanism of action

Calpain inhibition

Biological functions

Cytoskeletal remodelingSignal transductionLimited proteolysisCell differentiation

Disease associations

Neurodegenerative diseaseAlzheimer's diseaseOther

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