Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Calpain 2 large subunit (m-calpain) (m-calpain)
- Target
- m-calpain
- Molecular classification
- Enzyme, Protease
01
Overview
M-calpain is a calcium-dependent cysteine protease involved in various cellular processes, including cytoskeleton remodeling, signal transduction, and apoptosis. It is a heterodimer composed of a large catalytic subunit (CAPN2) and a small regulatory subunit (CAPNS1). Activation of m-calpain requires calcium binding, which induces a conformational change that enables proteolytic activity. This enzyme plays a crucial role in both physiological and pathological conditions, making it a potential therapeutic target for diseases related to its dysregulation.
- Other names
- Calpain IIm-calpain large subunitCalpain-2
02
Mechanism of action
Drugs inhibit calpain by blocking the active site or altering calcium binding, which is essential for its activation.
03
Biological functions
Cytoskeleton remodelingSignal transductionCell motilityMembrane repairApoptosisNecrosisProtein degradation
04
Disease associations
Neurodegenerative diseaseMuscle diseaseCancer progression
05
Safety considerations
Potential for unintended proteolytic activity, which could affect cell viability or function.
06
Interacting drugs
Calpain inhibitors (e.g., calpain inhibitor III, calpeptin)
07
Biomarkers
None specifically identified for m-calpain alone; however, general markers for calpain activity might include degradation products of substrates.
Beyond the preview
Go deeper on Calpain 2 large subunit (m-calpain) (m-calpain).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Calpain 2 large subunit (m-calpain) (m-calpain).