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Calpain-6 (CAPN6)
- Target
- CAPN6
- Molecular classification
- Enzyme (atypical, non-proteolytic calpain family member), Cytoskeletal regulator, C2 domain containing protein
01
Overview
Calpain-6 (CAPN6) is an atypical, non-proteolytic member of the calpain family of calcium-dependent cysteine proteases, but unlike most calpains, it lacks proteolytic activity due to active site mutations[1][2][3][5][6]. CAPN6 is highly expressed in embryonic muscle and placenta and acts as a multifunctional regulator of cytoskeletal dynamics, microtubule stabilization, and cell migration, where it can influence actin organization and cell differentiation. In muscle, it suppresses myogenic differentiation and regeneration. CAPN6 is also implicated in the inhibition of apoptosis and promotion of angiogenesis in tumorigenesis, suggesting potential relevance to cancer. Its unique absence of protease activity distinguishes it within the calpain family, and it has been proposed as a possible therapeutic target in certain muscle diseases and cancers[1][2][3][5][6].
- Other names
- CalpMCANPXCAPNXcalpamodulinDJ914P14.1calpain-like protease X-linked
02
Biological functions
Regulation of cytoskeletal dynamicsRegulation of microtubule stabilitySuppression of skeletal muscle differentiation and regenerationModulation of cell migration and lamellipodia formationRegulation of cell fate during development
03
Disease associations
Cancer (tumor formation via inhibition of apoptosis and promotion of angiogenesis)LeiomyosarcomaLeiomyomaPossible roles in neurodegenerative disease (by general association of calpains[1][5][6])Muscular dystrophy/atrophy (suggested target to regulate muscle differentiation and repair[2][3])
04
Safety considerations
Possible involvement in tumorigenesis due to suppression of apoptosis and promotion of angiogenesis[1][5]Therapeutic modulation may impact skeletal muscle growth or placental development[2][3]
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