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Target intelligence / Profile preview
Calpain-9
- Molecular classification
- Enzyme, Cysteine protease
01
Overview
Calpain-9 is a calcium-dependent, non-lysosomal cysteine protease predominantly expressed in the stomach and small intestine. It plays a role in cytoskeletal remodeling and cell differentiation. Calpain-9 is downregulated in gastric cancer and its loss protects against experimentally induced fibrosis, making it a potential therapeutic target.
- Other names
- GC36nCL-4calpain 9
02
Mechanism of action
Cysteine protease inhibition
03
Biological functions
Cytoskeletal remodelingCell differentiationCalcium-dependent proteolysis
04
Disease associations
Gastric cancerFibrosis
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