Calponin 2 pseudogene 3 (CNN2P3)

Calponin 2 pseudogene 3 (CNN2P3) is one of several pseudogenes of the functional calponin 2 gene (CNN2), which is located on chromosome 19p13.3 in humans and encodes a thin filament-associated protein involved in actin cytoskeleton regulation, particularly in smooth muscle contraction and cell adhesion[6][5][2]. CNN2P3 itself is a pseudogene, meaning it is a noncoding DNA sequence that resembles the functional CNN2 gene but contains mutations or alterations (such as stop codons, frameshifts, or missing regulatory sequences) that prevent it from being expressed as a functional protein[2][6]. Several pseudogenes of CNN2 have been identified in the human genome on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22[2][6]. There is currently no evidence that CNN2P3 is expressed or has a biological, pharmacological, or disease role. The functional, protein-coding gene is calponin 2 (CNN2), whereas CNN2P3 is a pseudogene. If a therapeutic or biological inquiry references CNN2P3, this is likely to be incorrect or irrelevant unless for purposes of studying pseudogene regulation or genomic mapping, not drug targeting. Pseudogenes may be incorrectly annotated as potential targets in some databases—careful verification is required. The canonical therapeutic target, if desired, would be "Calponin 2" (CNN2), not CNN2P3[5][6][2]. CNN2P3 is a nonfunctional pseudogene of the calponin 2 gene, has no known biological or clinical function, and is not a drug target[2][6][5]. The entry is best flagged as not a legitimate therapeutic or functional target.

Other names

CNN2P3calponin II pseudogene 3calponin 2 processed pseudogene 3pseudogene of CNN2 on chromosome 3

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