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Target intelligence / Profile preview
cAMP-dependent Protein Kinase (PKA)
- Target
- PKA
- Molecular classification
- Serine/threonine kinase, Enzyme, Protein kinase
01
Overview
cAMP-dependent protein kinase (PKA) is a family of enzymes that catalyze the phosphorylation of serine and threonine residues in target proteins. PKA activation is triggered by the binding of cyclic AMP (cAMP) to its regulatory subunits, leading to the release of active catalytic subunits. PKA plays a critical role in various cellular processes, including signal transduction, gene expression, and metabolism. In the context of astrocytes, PKA regulates glutamate homeostasis by influencing glutamate transporter expression and modulating calcium-dependent glutamate release.
- Other names
- Protein Kinase AcAMP-regulated protein kinase
02
Mechanism of action
PKA is activated by cAMP, leading to phosphorylation of downstream target proteins and modulation of their activity.
03
Biological functions
Signal transductionPhosphorylationRegulation of gene expressionRegulation of cellular metabolismRegulation of ion channel activityGlutamate homeostasis
04
Disease associations
Neurodegenerative diseasesCancerCardiovascular diseasesInflammationNeurological disorders
05
Safety considerations
Off-target effects due to broad substrate specificityPotential for dysregulation of multiple signaling pathways
06
Interacting drugs
cAMP analogs
1 more in the full profile.
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