cAMP-dependent protein kinase type I-alpha regulatory subunit mRNA (PRKAR1A mRNA)

The query "mRNA of Protein Kinase A regulatory subunit I alpha" refers specifically to the messenger RNA (mRNA) transcript that encodes the **cAMP-dependent protein kinase type I-alpha regulatory subunit** (gene symbol: PRKAR1A). While the mRNA is essential for the expression of the PRKAR1A protein, which functions as the regulatory subunit of type I protein kinase A (PKA), *mRNA itself is not considered a direct therapeutic target* in the same sense as receptors, enzymes, or protein complexes[4][5]. Rather, research and clinical focus relate to the PRKAR1A protein product, not its mRNA—except in the context of genetic tests, gene expression studies, or RNA-targeting therapeutics. If your intention is to retrieve structured information about a therapeutic protein target, the correct target should be the **PRKAR1A protein** (the protein product of the mRNA)[5][7][8].\n\n**Clarification:** \n- The PRKAR1A mRNA is the transcript, not the druggable protein. \n- The appropriate canonical form for a therapeutic target is "cAMP-dependent protein kinase type I-alpha regulatory subunit" or "PRKAR1A" (for the protein), not its mRNA[5][8].\n- Please clarify if you are interested in RNA interference, antisense, or other RNA-targeting modalities that may treat the mRNA as a drug target, which is rare and very specific.\n\n**Summary of Correct Entity for Target Assessment:** \n- The **PRKAR1A gene** encodes the regulatory subunit type I-alpha of protein kinase A, a critical modulator of cAMP signaling, with known roles in endocrine tumor syndromes (e.g., Carney complex) and potentially other diseases[4][5][7]. \n- The **PRKAR1A protein** is a validated molecular target with therapeutic and biomarker relevance. \n- The **mRNA** is not conventionally classified as a therapeutic target except in specialized gene-targeted therapies.\n\n**Recommendation:** \n- Use "cAMP-dependent protein kinase type I-alpha regulatory subunit" (PRKAR1A) as the canonical target for drug discovery, therapeutic, or biomarker purposes[5][8].\n- Use "PRKAR1A mRNA" only for gene expression, RNA biology, or RNA-targeting therapeutic queries.

Other names

PRKAR1A mRNAmRNA of protein kinase A regulatory subunit I alpha