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cAMP-regulated phosphoprotein 19 (ARPP19)
- Target
- ARPP19
- Molecular classification
- Other (phosphoprotein/protein phosphatase inhibitor), Intrinsically disordered protein (IDP)
01
Overview
cAMP-regulated phosphoprotein 19 (ARPP19) is an intrinsically disordered phosphoprotein that functions as a specific inhibitor of protein phosphatase 2A (PP2A) during mitosis[1][2][3]. ARPP19 is phosphorylated by kinases such as MASTL, and the phosphorylated form binds to the B55 regulatory subunit of PP2A, leading to inhibition of the phosphatase and regulation of G2/M cell cycle transition[1]. The ARPP19/PP2A axis is critical for mitotic progression and cell cycle control. Structurally, ARPP19 lacks a stable 3D fold but contains transient helices and engages in multiple conformational states[2]. Dysfunction or dysregulation of ARPP19 has been associated with disease states including cancer and certain brain malformation syndromes[2][3].
- Other names
- ARPP-19ARPP19ARPP16ARPP-16ENSALendosulfine alpha-likecAMP-regulated phosphoprotein 19kDacyclic AMP phosphoprotein 19 kD
02
Mechanism of action
Inhibition of PP2A:B55 holoenzyme by direct binding after phosphorylation by kinases such as MASTL or PKA
03
Biological functions
Regulation of mitosisInhibition of protein phosphatase 2A (PP2A)Signal transductionRegulation of cell cycle (G2/M transition)
04
Disease associations
CancerMega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformationsNeurodegenerative diseases (suggested by IDP status and regulation of PP2A, which is widely implicated in such diseases)Cardiovascular disease (IDP involvement)
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