Campylobacter jejuni capsular polysaccharide (CPS)

The **Campylobacter jejuni capsular polysaccharide** is a surface-exposed carbohydrate polymer that encapsulates *C. jejuni*, providing protection against host defenses and contributing to bacterial virulence[1][2][5][6][7][8]. Its complex structure varies significantly across strains, featuring diverse sugars and modifications that complicate serotyping and immune recognition. CPS acts as a major antigen and virulence factor, making it a principal target for vaccine development. Despite its promise as an immunogen, CPS-based vaccines face challenges due to molecular mimicry with host structures (risk of triggering autoimmunity, e.g., Guillain-Barré syndrome), phase-variable expression (which affects consistency of immune targeting), and the inherently weak immunogenicity of polysaccharides without conjugation to carrier proteins[2][6][8]. Consequently, substantial research focuses on CPS composition, biosynthesis, and the development of safe, effective immunogenic formulations against *C. jejuni*[3][8].

Other names

C. jejuni capsuleC. jejuni capsule polysaccharideC. jejuni CPSCapsule polysaccharide of Campylobacter jejuni

Induction of immune response (via CPS-conjugated vaccines or purified CPS as immunogens)