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Target intelligence / Profile preview
Cancer Antigen 125 (CA125/MUC16)
- Target
- CA125/MUC16
- Molecular classification
- Mucin, Glycoprotein
01
Overview
Cancer Antigen 125 (CA125), also known as MUC16, is a high molecular weight glycoprotein and a member of the mucin family. It is involved in cell adhesion, tumor proliferation, metastasis, and immune modulation. Elevated serum levels are associated with epithelial ovarian cancer and are used for monitoring disease progression and response to therapy. It is an emerging target for antibody-mediated immunotherapy.
- Other names
- MUC16Carbohydrate Antigen 125mucin 16
02
Mechanism of action
Antibody-mediated immunotherapy targeting epitopes within SEA domain
03
Biological functions
Cell adhesionTumor proliferationMetastasisImmune modulation
04
Disease associations
Cancer
05
Safety considerations
Lack of specificity for general population screening
06
Biomarkers
Ovarian cancer progressionTreatment response in ovarian cancerOvarian cancer relapseDisease progression in ovarian cancer
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