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Target intelligence / Profile preview
Cancer-Associated Fibroblast (CAF)
- Target
- CAF
- Molecular classification
- Other
01
Overview
Cancer-associated fibroblasts (CAFs) are a heterogeneous population of activated fibroblasts found within the tumor microenvironment. They acquire pro-tumorigenic properties that support cancer progression through multiple mechanisms, including extracellular matrix remodeling, promotion of angiogenesis, immune modulation, support of cancer stemness, and contribution to therapy resistance. CAFs are being actively investigated as therapeutic targets.
- Other names
- Tumor-associated fibroblastCarcinogenic-associated fibroblastActivated fibroblast
02
Mechanism of action
Inhibition of key signaling pathways involved in activation/function or targeting specific surface proteins unique to CAF subpopulations for drug delivery or depletion therapies.
03
Biological functions
Extracellular matrix remodelingAngiogenesis promotionImmune modulationSupport of cancer stemnessRegulation of tumor microenvironment
04
Disease associations
CancerTherapy ResistanceMetastasis
05
Safety considerations
Potential for off-target effects on normal fibroblastsDevelopment of resistance to CAF-targeted therapiesComplex and heterogeneous nature of CAF populations
06
Biomarkers
α-SMAFAPPDGFRα/β
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