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Target intelligence / Profile preview
Cancer-associated fibroblast activity (TGFβ₁ production)
- Molecular classification
- Cytokine production, Cellular process, Growth factor signaling
01
Overview
Cancer-associated fibroblast activity, specifically the production of TGFβ₁, is a key driver of tumor progression. TGFβ₁, secreted by CAFs, induces myofibroblast differentiation, promotes extracellular matrix remodeling, modulates the immune response, enhances metabolic support for cancer cells, and drives therapy resistance. Targeting this activity represents a potential therapeutic strategy.
- Other names
- CAF activity (TGFβ₁ production)Cancer-associated fibroblast-derived TGFβ₁TGFβ₁ production by CAFs
02
Mechanism of action
Inhibition of TGFβ signaling pathway
03
Biological functions
CAF activationExtracellular matrix remodelingImmune modulationMetabolic reprogrammingTumor promotionMetastasisTherapy resistance
04
Disease associations
CancerFibrosis
05
Safety considerations
Potential for off-target effects on normal fibroblastsContext-dependent roles of TGFβ₁ (tumor suppressor vs. promoter)Possible promotion of other compensatory pathways
06
Interacting drugs
LY2109761
07
Biomarkers
High stromal TGFβ₁ expressionLoss of caveolin-1 (Cav-1) in stroma
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