Target intelligence / Profile preview

Cancer Cell (Oncolysis)

Molecular classification: Cell, Epithelial, Mesenchymal

Overview

Cancer cells are the primary target for oncolytic therapies, particularly oncolytic viruses (OVs). Oncolysis refers to the process by which these viruses selectively infect and destroy cancer cells while sparing normal, healthy tissue. This selectivity is due to unique features of cancer cells, such as defects in antiviral response pathways and altered oncogenic signaling that make them more susceptible to viral infection and replication.

Other names: Malignant CellTumor Cell

Mechanism of action

Direct lysis & induction/augmentation of host antitumor immunity

Biological functions

Cell proliferationCell survivalTumorigenesisMetastasisAngiogenesisEvading immune destruction

Disease associations

Cancer

Safety considerations

Off-target effectsImmune-related adverse eventsInsertional mutagenesisPre-existing immunity to oncolytic viruses

Interacting drugs

Oncolytic Viruses

2 more in the full profile.

Biomarkers

Tumor antigensViral loadImmune cell infiltration

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