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Cancer Cell (Selective Replication)
- Molecular classification
- Other
01
Overview
Cancer cell selective replication refers to the ability of certain therapeutic agents—most notably, engineered viruses or small molecules—to preferentially replicate within and kill cancer cells while sparing normal, healthy cells. This selectivity is often achieved by exploiting unique molecular defects or stress responses present in cancer cells but absent in normal tissue.
02
Mechanism of action
Exploits oncogenic signaling-induced vulnerabilities: high RS; defective checkpoints; altered metabolism
03
Biological functions
Cell proliferationCell deathDNA replication
04
Disease associations
Cancer
05
Safety considerations
Off-target effects on normal cellsDevelopment of resistanceImmune response to viral vectorsNeurovirulence (for some viral vectors)
06
Interacting drugs
Oncolytic viruses (HSV variants)
4 more in the full profile.
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